Treating cutaneous aging with patented technologies

The subcutaneous fat is significantly lost from the dorsum of the hand, face and shin, but accumulates in the waist or thigh (Kligman et al.1985; Farage et al.2007). In the epidermis, signs of aging include lowering of the levels of collagen IV and collagen VII at the basement membrane, flattening of the rete ridge, thinning of the epidermis, and lowering of the levels of ceramides, free fatty acids, squalene and epidermal cholesterol (El-Domyati et al.2002; Hayashi et al.2003; Sandby-Moller et al.2003; Neerken et al.2004; Fore 2006). In the dermis, aging leads to fragmentation of elastin, an increase in collagen degradation, and a decrease in production of dermal collagen, proteoglycans and glycosaminoglycans.

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